Drug-induced liver injury (DILI) is associated with the use of certain OTC (over-the-counter) prescription drugs, as well as dietary supplements. Doctors say that DILI is difficult to predict, diagnose and manage. Einar S. Björnsson and colleagues carried out an Icelandic population-based study, which found there were 19.1 cases of DILI per 100,000 people per year. […]
Drug-induced liver injury cases rising
Drug-induced liver injury (DILI) is associated with the use of certain OTC (over-the-counter) prescription drugs, as well as dietary supplements. Doctors say that DILI is difficult to predict, diagnose and manage. Einar S. Björnsson and colleagues carried out an Icelandic population-based study, which found there were 19.1 cases of DILI per 100,000 people per year. The last similar type study, carried out in France (1997-2000), reported 13.9 cases of DILI per 100,000 people annually. Medications most commonly associated with drug-induced liver injury were: Amoxicillin-clavulante – a penicillin antibiotic used to treat infections; Azathioprine – an immunosuppressive medication used in organ transplantation and autoimmune diseases; Infliximab – a monoclonal antibody against tumor necrosis factor alpha used to treat autoimmune disease.
